Chapter 1 – Infectious/Parasitic Diseases
B88.01 – Infestation by Demodex mites
– AKA “face mites”
B88.09 – Other acariasis
Chapter 2 – Neoplasms
C50.A0 – Malignant inflammatory neoplasm of unspecified, breast
C50.A1 – Malignant inflammatory neoplasm of right breast
C50.A2 – Malignant inflammatory neoplasm of left breast
Chapter 3 – Blood/Blood Forming Organs
Includes new codes for:
- Leukocyte adhesion deficiency
- Other functional disorders of polymorphonuclear neutrophils
- Functional disorders of polymorphonuclear neutrophils, unspecified
• D71.1 – Leukocyte adhesion deficiency
• D71.8 – Other functional disorders of polymorphonuclear neutrophils
• D71.9 – Functional disorders of polymorphonuclear neutrophils, unspecified
Chapter 4 – Endocrine/Metabolic
Includes new codes for:
- Type 2 diabetes mellitus without complications in remission
- Primary and secondary hyperoxaluria
- Familial hypercholesterolemia
- Other disorders of mineral metabolism
- Lipodystrophy, not elsewhere classified
- Mitochondrial metabolism disorders
E11.A – Type 2 diabetes mellitus without complications in remission
E72.530 – Primary hyperoxaluria, type 1
E72.538 – Other primary hyperoxaluria
E72.539 – Primary hyperoxaluria, unspecified
E72.540 – Dietary hyperoxaluria
E72.541 – Enteric hyperoxaluria
E72.548 – Other secondary hyperoxaluria
E72.549 – Secondary hyperoxaluria, unspecified
E78.010 – Homozygous familial hypercholesterolemia [HoFH]
E78.011 – Heterozygous familial hypercholesterolemia [HeFH]}
E78.019 – Familial hypercholesterolemia, unspecified
E83.820 – Generalized arterial calcification of infancy with unspecified genetic causality
E83.821 – ENPP1 deficiency causing generalized arterial calcification of infancy
E83.822 – ENPP1 deficiency causing autosomal recessive hypophosphatemic rickets type 2
E83.823 – ABCC6 deficiency causing generalized arterial calcification of infancy
E83.824 – ABCC6 deficiency causing pseudoxanthoma elasticum • E83.825 – CD73 deficiency causing arterial calcification
E88.10 – Lipodystrophy, unspecified
E88.11 – Partial lipodystrophy
E88.12 – Generalized lipodystrophy
E88.13 – Localized lipodystrophy
E88.14 – HIV-associated lipodystrophy
E88.19 – Other lipodystrophy, NEC
Chapter 6 – Nervous
Includes new codes for:
- Primary progressive apraxia of speech
- Relapsing-remitting multiple sclerosis
- Primary and secondary progressive multiple sclerosis
- Multiple sclerosis, unspecified
- Limb girdle muscular dystrophies
G31.87 – Primary progressive apraxia of speech
G71.036 – Limb girdle muscular dystrophy due to fukutin related protein dysfunction
G35.A – Relapsing -remitting multiple sclerosis
G35.B0 – Primary progressing multiple sclerosis, unspecified
G35.B1 – Active primary progressive multiple sclerosis
G35.C0 – Secondary progressive multiple sclerosis, unspecified
G35.C1 – Active secondary progressive multiple sclerosis
G35.C2 – Non -active secondary progressive multiple sclerosis
G35.D – Multiple sclerosis, unspecified
Chapter 7 – Eye
Category H01.8- Other specified inflammation (right/left and upper/lower
eyelids)
H05.831 – Thyroid orbitopathy, right orbit
H05.832 – Thyroid orbitopathy, left orbit
H05.833 – Thyroid orbitopathy, bilateral
H05.839 – Thyroid orbitopathy, unspecified orbit
H40.841 – Neovascular secondary angle closure glaucoma, right eye
H40.842 – Neovascular secondary angle closure glaucoma, left eye
H40.843 – Neovascular secondary angle closure glaucoma, bilateral
H40.849 – Neovascular secondary angle closure glaucoma, unspecified eye
Chapter 9 – Circulatory
I27.840 – Fontan-associated liver disease [FALD]
I27.841 – Fontan-associated lymphatic dysfunction
I27.848 – Other Fontan-associated condition
I27.849 – Fontan-related circulation, unspecified
Chapter 12 – Skin/Subcutaneous Tissues
Includes new codes for:
- Cutaneous abscess of flank
- Furuncle of flank
- Cellulitis of flank
- Acute lymphangitis of flank
- Non-pressure chronic ulcer abdomen, chest, neck, face, and groin
- Non-pressure chronic ulcer of upper limb, not elsewhere classified
- Non-pressure chronic ulcer of upper arm
- Non-pressure chronic ulcer of forearm
- Non-pressure chronic ulcer of hand
L02.217 – Cutaneous abscess of flank
L02.227 – Furuncle of flank
L03.31A – Cellulitis of flank
L03.32A – Acute lymphangitis of flank
Chapter 13 – Musculoskeletal
M05.A – Abnormal rheumatoid factor and anti-citrullinated protein antibody with
rheumatoid arthritis
Chapter 14 – Genitourinary
Includes new codes for:
- Acute nephritic syndrome with immune complex membranoproliferative glomerulonephritis
- Nephrotic syndrome with immune complex membranoproliferative glomerulonephritis
- Hereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease
N00.B1 –Acute nephritic syndrome with idiopathic immune membranoproliferative glomerulonephritis (IC-MPGN)
N00.B2 – Acute nephritic syndrome with secondary immune complex membranoproliferative glomerulonephritis
N04.B1 – Nephrotic syndrome with idiopathic immune membranoproliferative glomerulonephritis
N04.B2 – Nephrotic syndrome with secondary immune complex membranoproliferative glomerulonephritis
N07.B – Hereditary nephropathy, NEC with APOL-1-mediated kidney disease
Chapter 17 – Congenital
Includes new codes for:
- Hao-Fountain Syndrome
- CTNNB1 syndrome
- Kabuki syndrome
- other specified congenital malformations
- Usher syndrome
- Other specified chromosome abnormalities
- Genetic disorders, not elsewhere classified
- Neurodevelopmental disorders related to specific genetic pathogenic variants
- Neurodevelopmental disorders related to pathogenic variants in specific genes
- Neurodevelopmental disorders related to pathogenic variants in other specific genes
Q87.87 – Hao-Fountain syndrome
Q87.88 – CTNNB1 syndrome
Q89.81 – Kabuki syndrome
Q89.89 – Other specified congenital malformations
Q99.89 – Other specified chromosome abnormalities
Q99.811 – Usher syndrome, Type 1
Q99.812 – Usher syndrome, Type 2
Q99.813 – Usher syndrome, Type 3
Q99.818 – Other Usher syndrome
Q99.819 – Usher syndrome, unspecified
QA0.0101 – SCN2A-related neurodevelopmental disorder
QA0.0102 – CACNA1A-related neurodevelopmental disorder
QA0.0109 – Neurodevelopmental disorder related to pathogenic variant in other ion channel gene
QA0.011 – Neurodevelopmental disorders related to pathogenic variants in glutamate receptor genes
QA0.0131 – SLC6A1-releated disorder
QA0.0131 – SLC6A1-releated disorder
QA0.0139 – Neurodevelopmental disorder related to pathogenic variant in other transporter or solute carrier gene
QA0.0141 – Syntaxin-binding protein 1-related disorder
QA0.0142 – DLG4-related synaptopathy
QA0.0149 – Neurodevelopmental disorder, related to pathogenic variant in other synapse related gene
QA0.0151 – FOXG syndrome
QA0.0159 – Neurodevelopmental disorder, related to other genes associated with transcription and gene expression
QA0.8 – Other neurodevelopmental disorders related to pathogenic variants in other specific genes
Chapter 18 – Symptoms/Signs
Includes new codes for:
- Pelvic and perineal pain
- Abdominal pain of multiple sites
- Flank tenderness
- Pain localized to flank
- Cannabis hyperemesis syndrome
- Costovertebral (angle) tenderness
- Abnormal rheumatoid factor and anti-citrullinated protein antibody without rheumatoid arthritis
- Other specified abnormal immunological findings in serum
R10.20 – Pelvic and perineal pain, unspecified side
R10.21 – Pelvic and perineal pain, right side
R10.22 – Pelvic and perineal pain, left side
R10.23 – Pelvic and perineal pain, bilateral
R10.24 – Suprapubic pain
R10.85 – Abdominal pain of multiple sites
R10.8A1 – Right flank tenderness
R10.8A2 – Left flank tenderness
R10.8A3 – Suprapubic tenderness
R10.8A9 – Flank tenderness, unspecified
R10.A0 – Flank pain, unspecified side
R10.A1 – Flank pain, right side
R10.A2 – Flank pain, left side
R10.A3 – Flank pain, bilateral
R11.16 – Cannabis hyperemesis syndrome
R39.851 – Costovertebral (angle) tenderness, right side
R39.852 – Costovertebral (angle) tenderness, left side
R39.853 – Costovertebral (angle) tenderness, bilateral
R39.859 – Costovertebral (angle) tenderness, unspecified side
R76.81 – Abnormal rheumatoid factor and anti-citrullinated protein antibody
without rheumatoid arthritis
R76.89 – Other specified abnormal immunological findings in serum
Chapter 19 – Injury/Poisonings
Includes new codes for:
- Contusion of abdominal wall
- Contusion of groin
- Contusion of flank (latus) region
- Abrasion of flank
- Blister (nonthermal) of flank
- External constriction of flank
- Superficial foreign body of flank
- Insect bite (nonvenomous) of flank
- Other superficial bite of flank
- Unspecified superficial injury of flank
- Unspecified open wound of abdominal wall without penetration into peritoneal cavity
- Laceration without foreign body of abdominal wall without penetration into peritoneal cavity
- Laceration without foreign body of abdominal wall without penetration into peritoneal cavity
- Puncture wound of abdominal wall without foreign body without penetration into peritoneal cavity
- Puncture wound of abdominal wall with foreign body without penetration into peritoneal cavity
- Open bite of abdominal wall without penetration into peritoneal cavity
- Unspecified open wound of abdominal wall with penetration into peritoneal cavity
- Laceration without foreign body of abdominal wall with penetration into peritoneal cavity
- Laceration with foreign body of abdominal wall with penetration into peritoneal cavity
- Puncture wound without foreign body of abdominal wall with penetration into peritoneal cavity
- Puncture wound with foreign body of abdominal wall with penetration into peritoneal cavity
- Open bite of abdominal wall with penetration into peritoneal cavity
- Poisoning by, adverse effect of and underdosing of fluoroquinolone antibiotics
- Toxic effect of xylazine
- Effects of war theater
- Anaphylactic reaction due to milk and dairy products
- Anaphylactic reaction due to eggs
- Other adverse food reactions due to milk and dairy products
- Other adverse food reaction due to eggs
- Other adverse food reactions, not elsewhere classified
S30-S31 for injuries involving abdominal wall, groin and flank
– Contusions
– Abrasions
– Blisters
– Superficial foreign body
– Insect bites
– Open wounds
– Lacerations
– Puncture wounds
– Open bite
T36.AX1- Poisoning, adverse effect of, underdosing of fluoroquinolone
Requires 7th character for episode of care
T75.830- Gulf war illness
Requires 7th character for episode of care
T75.838- Effects of other war theater
Requires 7th character for episode of care
T78.070– Anaphylactic reaction due to milk/dairy products with tolerance to baked milk
T78.071- Anaphylactic reaction due to milk/dairy products with reactivity to baked milk
T78.079- Anaphylactic reaction due to milk/dairy products, unspecified
Requires 7th character for episode of care
T78.080– Anaphylactic reaction due to egg with tolerance to baked egg
T78.081- Anaphylactic reaction due to egg with reactivity to baked egg
T78.089- Anaphylactic reaction due to eggs, unspecified
Requires 7th character for episode of care
T78.110– Other adverse food reactions due to milk/dairy products with tolerance to baked milk
T78.111- Other adverse food reactions due to milk/dairy products with reactivity to baked milk
T78.119– Other adverse food reactions due to milk/dairy products with baked milk tolerance/reactivity, unspecified
Requires 7th character for episode of care
T78.120 – Other adverse food reaction due to egg with tolerance to baked egg
T78.121 – Other adverse food reaction due to egg with reactivity to baked egg
T78.129 – Other adverse food reaction due to egg, with baked egg tolerance/reactivity unspecified
T78.19X- Other adverse food reactions, NEC
Requires 7th character for episode of care
Chapter 20 – External Causes
Includes new codes for:
- Other sharp object entering into or through a natural orifice
- Fishing hook entering through skin
- Blast overpressure in war operations
- Blast overpressure in military operations
- Other outdoor activity
W44.H9X- Other sharp object entering into or through a natural orifice
W45.3XX- Fish hook entering through skin
Requires 7th character for episode of care
Y36.A1X- Low level blast overpressure in war operations
Y36.A2X – High level blast overpressure in war operations
Y37.A1X- Low level blast overpressure in military operations
Y37.A2X – High level blast overpressure in military operations
Requires 7th character for episode of care
Y93.L1- Activity, splitting wood
Y93.L9 – Activity, other outdoor activity
Chapter 21 – Factors Influencing Health
Includes new codes for:
- Genetic susceptibility to malignant neoplasm
- Genetic susceptibility to kidney disease
- Encounter for other prophylactic surgery
- Financial insecurity
- Contact with and (suspected) exposure to war theater
- Family history of malignant neoplasm of fallopian tube(s)
- Family history of disorders of kidney and ureter
- Family history of exposure to diethylstilbestrol
- Personal history of malignant neoplasm of fallopian tube(s)
- Personal history of in-situ neoplasm of the fallopian tube(s)
- Allergy to milk products
- Allergy to eggs
- Personal risk factor of exposure to diethylstilbestrol
Z15.05 – Genetic susceptibility to malignant neoplasm of fallopian tube(s)
Z15.060 – Genetic susceptibility to colorectal cancer
Z15.068 – Genetic susceptibility to other malignant neoplasm of digestive
system
Z15.07 – Genetic susceptibility to malignant neoplasm of urinary tract
Z15.3 – Genetic susceptibility to kidney disease
Z40.81 – Encounter for prophylactic surgery for removal of ovary(s) for persons without known genetic/familial risk factors
Z40.82 – Encounter for prophylactic surgery for removal of fallopian tube(s) for persons without known genetic/familial risk factors
Z40.89 – Encounter for other prophylactic surgery
Z59.861 – Financial insecurity, difficulty paying for utilities
Z59.868– Other specific financial insecurity
Z59.869 – Financial insecurity, unspecified
Z77.31 – Contact with and (suspected) exposure to Gulf War theater
Z77.39 – Contact with and (suspected) exposure to other war theater
Z80.44 – Family history of malignant neoplasm of fallopian tube(s)
Z84.11 – Family history of APOL-1 mediated kidney disease [AKMD]
Z84.19 – Family history of other disorders of kidney and ureter(s)
Z84.A – Family history of exposure to diethylstilbestrol
Z85.4A – Personal history of malignant neoplasm of fallopian tube(s)
Z86.00A – Personal history of in-situ neoplasm of the fallopian tubes
Z91.0110 – Allergy to milk products, unspecified
Z91.0111 – Allergy to milk products with tolerance to baked milk
Z91.0112 – Allergy to milk products with reactivity to baked milk
Z91.0120 – Allergy to eggs, unspecified
Z91.0121 – Allergy to eggs with tolerance to baked egg
Z91.0122 – Allergy to eggs with reactivity to baked egg
Z91.B – Personal risk factor of exposure to diethylstilbestrol



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